Quinolines and derivatives
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Filtered Search Results
Medchemexpress LLC MHY1485 | 326914-06-1 | 99.9% | 200 MG
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MHY1485 is a potent, cell-permeable mTOR activator that targets the ATP domain of mTOR. It inhibits autophagy by suppressing the fusion between autophagosomes and lysosomes.
- Inhibits GCDC-induced autophagic activity in HCC cells
- Increases LC3II/LC3I ratio in rat liver Ac2F cells
- Dose-dependently increases phosphorylation of mTOR at Ser2448 and upregulates 4E-BP1 phosphorylation in Ac2F cells
- Blocks autophagy signaling induced by follicle-stimulating hormone (FSH) in female ICR mice
- Increases p-mTOR and p-S6K1 expression levels in mice
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eMolecules Chem-Impex Sulfo-N-succinimidyl 4-(maleimidomethyl)cyclohexane-1-carboxylate sodium salt 100mg 272386940 23033 0 000 92921-24-9 MFCD00054978 436 370 C16H17N2NaO9S
Chem-Impex Sulfo-N-succinimidyl 4-(maleimidomethyl)cyclohexane-1-carboxylate sodium salt 100mg 272386940 23033 0 000 92921-24-9 MFCD00054978 436 370 C16H17N2NaO9S
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AdipoGen Propidium Iodide Solution
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Chemical. CAS 25535-16-4. Formula C27H34I2N4. MW 668.39. Synthetic. Most common red-fluorescent nuclear stain. Membrane impermeant and generally excluded from viable cells. It can easily penetrate dead or damaged cells and as such is commonly used for identifying cell viability in a population or as a counterstain in multicolor fluorescent techniques. It binds to DNA and RNA by intercalating between the bases. Suitable for use in fluorescence microscopy, confocal laser scanning microscopy, flow cytometry and fluorometry. Spectral data lambdaex=488-535nm, lambdaem=617nm.
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Apexbio Technology LLC Mycophenolate Mofetil 128794-94-5 200mg
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Mycophenolate Mofetil (128794-94-5) is a small-molecule inhibitor targeting inosine monophosphate dehydrogenase (IMPDH) isoforms I and II It is designed to selectively and reversibly inhibit IMPDH thereby disrupting de novo guanosine nucleotide biosynthesis Mycophenolate Mofetil exerts its biological activity primarily through non-competitive inhibition of IMPDH blocking the conversion of inosine monophosphate (IMP) to xanthosine monophosphate (XMP) In in vitro studies Mycophenolate Mofetil demonstrates inhibitory activity with IC50 values of 39 nM and 27 nM for IMPDH I and II respectively Based on these pharmacological properties Mycophenolate Mofetil holds research potential in studies on immunology purine metabolism regulation cell proliferation transplant rejection and autoimmune disease models
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eMolecules LEUPEPTIN HEMISULFATE 100MG
5000190007 LEUPEPTIN HEMISULFATE 100MG
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Apexbio Technology LLC Chelerythrine Chloride 3895-92-9 5mg
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Chelerythrine Chloride (CAS 3895-92-9) is a benzophenanthridine alkaloid widely utilized as a selective antagonist of protein kinase C (PKC) with an IC50 of 0 66 M It acts as a high-specificity inhibitor by targeting the kinase regulatory domain serving as a competitive inhibitor with respect to phosphate receptors and a non-competitive inhibitor toward ATP Chelerythrine also inhibits Bcl-xL inducing apoptosis in mouse embryonic fibroblasts (MEFs) with an IC50 of 1 1 M It activates the JNK1 and p38 pathways via MEKK1 and MKK4 contributing to its pro-apoptotic effects In cellular assays chelerythrine reduces cell viability (MTT IC50 2 6 M) and in animal studies promotes apoptosis through reactive oxygen species generation Its applications extend to research on kinase activity apoptosis antimicrobial activity and anti-inflammatory processes
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Apexbio Technology LLC β-Naphthoflavone 6051-87-2 200mg
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-Naphthoflavone (CAS 6051-87-2) also known as 5 6-benzoflavone is a small molecule that acts as a potent agonist of the aryl hydrocarbon receptor (AhR) Activation of AhR by -naphthoflavone upregulates the expression of metabolizing enzymes including multiple cytochrome P450 isoforms (CYPs) and uridine 5 -diphospho-glucuronosyltransferases (UGTs) This compound is widely utilized in biomedical research to investigate xenobiotic metabolism enzyme induction and the regulation of detoxification pathways Additionally it has been studied for its potential role in chemoprevention due to its modulatory effects on metabolic enzymes
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Chemscene ChemScene | 3-Aminoquinoline-8-carboxylic acid | 250MG | CS-0460356 | 0.97 | 1799412-39-7| MFCD28133462 | 188.19
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ChemScene | 3-Aminoquinoline-8-carboxylic acid | 250MG | CS-0460356 | 0.97 | 1799412-39-7| MFCD28133462 | 188.19
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Chemscene ChemScene | 7-Aminoquinoline-2-carboxylic acid | 250MG | CS-0376828 | 0.98 | 106139-28-0| MFCD18816931 | 188.19
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ChemScene | 7-Aminoquinoline-2-carboxylic acid | 250MG | CS-0376828 | 0.98 | 106139-28-0| MFCD18816931 | 188.19
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Medchemexpress LLC Cyclooctyne-O-amido-PEG4-VC-PAB-Gly-Gly-NH-O-CO-Exatecan | 97.3% | 1396.51 Da | 5 MG
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Cyclooctyne-O-amido-PEG4-VC-PAB-Gly-Gly-NH-O-CO-Exatecan is a drug-linker conjugate designed for antibody-drug conjugate (ADC) research; the construct contains an exatecan payload, a PEG4-VC-PAB cleavable linker, and a cyclooctyne reactive group for conjugation.
- Drug-linker conjugate for ADC research.
- Contains exatecan as the cytotoxic payload.
- Cyclooctyne reactive group suitable for bioorthogonal conjugation.
- PEG4-VC-PAB linker provides a cleavable spacer for payload release.
- Supplied at high purity suitable for research applications.
- Available in small pack sizes for early-stage research and conjugation development.
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Medchemexpress LLC Cyclooctyne-o-amido-peg4-vc-pab-gly-gly-nh-o-co-exatecan | 2699066-62-9 | 97.3% | 1396.51 | C69H90FN11O19 | 1 MG
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Cyclooctyne-O-amido-PEG4-VC-PAB-Gly-Gly-NH-O-CO-Exatecan is a cleavable drug-linker conjugate intended for antibody-drug conjugate (ADC) research, where Exatecan serves as the cytotoxic payload. Supplied as a solid for research use only, it is used in conjugation chemistry and ADC synthesis.
- Molecular formula: C69H90FN11O19.
- Molecular weight: 1396.51.
- Purity: 97.3%.
- Physical state: solid.
- Cas number: 2699066-62-9.
- Available sizes: 1 mg and 5 mg vials; larger quantities available by quotation.
- Storage: 4°C under nitrogen; in solvent: -80°C (up to 6 months) or -20°C (up to 1 month), stored under nitrogen.
- For research use only; not for human or veterinary use.
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eMolecules Chem-Impex Sulfo-N-succinimidyl 4-(maleimidomethyl)cyclohexane-1-carboxylate sodium salt 250mg 272386941 23033 0 000 92921-24-9 MFCD00054978 436 370 C16H17N2NaO9S
Chem-Impex Sulfo-N-succinimidyl 4-(maleimidomethyl)cyclohexane-1-carboxylate sodium salt 250mg 272386941 23033 0 000 92921-24-9 MFCD00054978 436 370 C16H17N2NaO9S
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Alkali Scientific ALKALI SCIENTIFIC INC
5000659621 ETHIDIUM BROMIDE DNA STAIN
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eMolecules Broadpharm DBCO-amine 250mg 254745543 BP-22066 96 000 1255942-06-3 MFCD22380759 276 339 C18H16N2O
Broadpharm DBCO-amine 250mg 254745543 BP-22066 96 000 1255942-06-3 MFCD22380759 276 339 C18H16N2O
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eMolecules EMOLECULES INC
NC3942582 1-OCTYLNONYL 8-2-HYDROXYETHY1G
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